By using a hybrid microfabrication approach, complex lab-on-chip devices can be produced. One example is the liver-on-chip as an in vitro liver model. The channel system is made by using the selective laser etching technique (SLE). Polymeric filters are integrated inside the prepared microfluidic system by using multi-photon polymerization (MPP). The channels in the glass along with polymeric micropillars form a microfluidic device where different types of inserted cells can form a complex cellular architecture and manipulate cell‑to-cell interactions. These devices can be applied in biomedical research since the possibility of combining both SLE and MPP offers convenient prototyping of fully functioning devices using only one tool.
Femtosecond microfabrication is a hybrid approach that combines laser ablation and multi-photon polymerization for lab-on-chip applications. This enables the rapid production of channels and filters in arbitrary geometries for devices such as a microfluidic macromolecule separator and a liver-on-chip model.
A feasibility study is composed of several steps, including researching methods for fabricating micro-structures, fabricating a micro-structure prototype, measuring and aligning the prototype with technical requirements, and finally preparing a study report.