The hybrid-fabrication approach enables rapid production of channels out of fused silica via laser ablation, while multiphoton polymerization is used to integrate fine-mesh 3D filters of arbitrary geometry inside the channel. To prove the effectiveness of this approach, a microfluidic macromolecule separator prototype is produced intended for new generation drug development and production. It is designed to separate low and high‑molecular-weight substances in mixture solutions. The polymer and glass components needed for these devices are selected and incorporated freely during the manufacturing process, bringing a new level of functionality to the device, and simplifying the fabrication workflow. Due to the versatility of multiphoton polymerization, various complex geometry filters can be implemented at very high resolutions. For example, the pores of this filter are 500 nm wide.
